Immunohistochemical expression of PTEN (phosphatase and tension homolog) in endometrial carcinoma

Background and objective: Different molecular alterations have been described in the pathogenesis of endometrial carcinoma, among themis mutation PTEN (phosphatase tension homolog), a tumor suppressor gene. This study aimed to detect immunoexpression carcinoma asses association between with clinicopathological parameters. Methods: cross-sectional retrospective was carried out January 2016-December 2021 Erbil city. A total 112 formalin fixed, paraffin embedded, archival tissue blocks abdominal hysterectomy samples were collected Erbilcity. The characteristics tumors revised, specimens analyzed immunohistochemically using monoclonal antibody clone 6H2.1 (Dako. Results: Seventy- seven cases (68.8%) labeled as negative for immunoexpression. While 35 (31.2%) positive significantly associated histological types (P = 0.001), while no significant found other Conclusion: Loss frequently seen endometrioid type than is carcinoma.